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1

Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence

Shin-ichiro Ikebe, Masashi Tanaka, Kinji Ohno, Wataru Sato, Kazuki Hattori, Tomoyoshi Kondo, Yoshikuni Mizuno, Takayuki Ozawa

Journal:

Biochemical and Biophysical Research Communications

Year:

1990

Language:

english

File:

PDF, 614 KB

english, 1990

2

Quantitative determination of deleted mitochondrial DNA relative to normal DNA in parkinsonian striatum by a kinetic PCR analysis

Takayuki Ozawa, Masashi Tanaka, Shin-ichiro Ikebe, Kinji Ohno, Tomoyoshi Kondo, Yoshikuni Mizuno

Journal:

Biochemical and Biophysical Research Communications

Year:

1990

Language:

english

File:

PDF, 1.65 MB

english, 1990

3

10.1038/33416

Shimizu, Nobuyoshi, Kitada, Tohru, Asakawa, Shuichi, Hattori, Nobutaka, Matsumine, Hiroto, Yamamura, Yasuhiro, Minoshima, Shinsei, Yokochi, Masayuki, Mizuno, Yoshikuni

Journal:

Year:

1998

Language:

english

File:

PDF, 335 KB

english, 1998

4

An update on the management of juvenile and young-onset Parkinson’s disease

Mizuno, Yoshikuni

Journal:

Future Neurology

Year:

2012

Language:

english

File:

PDF, 613 KB

english, 2012

5

A Microdeletion of D6S305 in a Family of Autosomal Recessive Juvenile Parkinsonism (PARK2)

Hiroto Matsumine, Yasuhiro Yamamura, Nobutaka Hattori, Tomonori Kobayashi, Tohru Kitada, Asako Yoritaka, Yoshikuni Mizuno

Journal:

Year:

1998

Language:

english

File:

PDF, 91 KB

english, 1998

6

Down-regulation of α-synuclein expression can rescue dopaminergic cells from cell death in the substantia nigra of Parkinson’s disease rat model

Hiromi Hayashita-Kinoh, Masanori Yamada, Takanori Yokota, Yoshikuni Mizuno, Hideki Mochizuki

Journal:

Biochemical and Biophysical Research Communications

Year:

2006

Language:

english

File:

PDF, 570 KB

english, 2006

7

Analysis of eighteen deletion breakpoints in the parkin gene

Shuichi Asakawa, Nobutaka Hattori, Atsushi Shimizu, Yoshiko Shimizu, Shinsei Minoshima, Yoshikuni Mizuno, Nobuyoshi Shimizu

Journal:

Biochemical and Biophysical Research Communications

Year:

2009

Language:

english

File:

PDF, 807 KB

english, 2009

8

Music therapy in parkinson's disease: Improvement of parkinsonian gait and depression with rhythmic auditory stimulation

Akito Hayashi, Masanori Nagaoka, Yoshikuni Mizuno

Journal:

Parkinsonism & Related Disorders

Year:

2006

Language:

english

File:

PDF, 56 KB

english, 2006

9

Colocalization of Bcl-2 and 4-hydroxynonenal modified proteins in microglial cells and neurons of rat brain following transient focal ischemia

Takao Urabe, Nobutaka Hattori, Mutsuko Yoshikawa, Hiroyo Yoshino, Koji Uchida, Yoshikuni Mizuno

Journal:

Neuroscience Letters

Year:

1998

Language:

english

File:

PDF, 354 KB

english, 1998

10

Reciprocal Ia inhibition in patients with asymmetric spinal spasticity

Yasuyuki Okuma, Yoshikuni Mizuno, Robert G Lee

Journal:

Clinical Neurophysiology

Year:

2002

Language:

english

File:

PDF, 116 KB

english, 2002

11

Inhibition of mitochondrial NADH-ubiquinone oxidoreductase activity and ATP synthesis by tetrahydroisoquinoline

Suzuki, Keiji, Mizuno, Yoshikuni, Yoshida, Mitsuo

Journal:

Neuroscience Letters

Year:

1988

Language:

english

File:

PDF, 202 KB

english, 1988

12

[ASME ASME 2015 International Technical Conference and Exhibition on Packaging and Integration of Electronic and Photonic Microsystems collocated with the ASME 2015 13th International Conference on Nanochannels, Microchannels, and Minichannels - San Francisco, California, USA (Monday 6 July 2015)] Volume 3: Advanced Fabrication and Manufacturing; Emerging Technology Frontiers; Energy, Health and Water- Applications of Nano-, Micro- and Mini-Scale Devices; MEMS and NEMS; Technology Update Talks; Thermal Management Using Micro Channels, Jets, Sprays - Formation Characteristics of Bio-Coke Produced From Waste Agricultural Biomass

Mizuno, Satoru, Ida, Tamio, Fuchihata, Manabu, Sanchez, Edmundo, Yoshikuni, Koji

Year:

2015

Language:

english

File:

PDF, 2.39 MB

english, 2015

13

Minimal Clinically Important Difference in Parkinson’s Disease as Assessed in Pivotal Trials of Pramipexole Extended Release

Hauser, Robert A., Gordon, Mark Forrest, Mizuno, Yoshikuni, Poewe, Werner, Barone, Paolo, Schapira, Anthony H., Rascol, Olivier, Debieuvre, Catherine, Fräßdorf, Mandy

Journal:

Parkinson's Disease

Year:

2014

Language:

english

File:

PDF, 1.22 MB

english, 2014

14

Polymorphism in the parkin gene in sporadic Parkinson's disease

Mei Wang, Nobutaka Hattori, Hiroto Matsumine, Tomonori Kobayashi, Hiroyo Yoshino, Akiko Morioka, Tohru Kitada, Shuichi Asakawa, Shinsei Minoshima, Nobuyoshi Shimizu, Yoshikuni Mizuno

Journal:

Annals of Neurology

Year:

1999

Language:

english

File:

PDF, 4.60 MB

english, 1999

15

Immunohistochemical and subcellular localization of parkin protein: Absence of protein in autosomal recessive juvenile parkinsonism patients

Hideki Shimura, Nobutaka Hattori, Shin-Ichiro Kubo, Mutsuko Yoshikawa, Tohru Kitada, Hiroto Matsumine, Shuichi Asakawa, Shinsei Minoshima, Yasuhiro Yamamura, Nobuyoshi Shimizu, Yoshikuni Mizuno

Journal:

Annals of Neurology

Year:

1999

Language:

english

File:

PDF, 4.60 MB

english, 1999

16

Increased 8-oxo-dGTPase in the mitochondria of substantia nigral neurons in Parkinson's disease

Hideki Shimura-Miura, Nobutaka Hattori, Dongchon Kang, Ken-Ichi Miyako, Yusaku Nakabeppu, Yoshikuni Mizuno

Journal:

Annals of Neurology

Year:

1999

Language:

english

File:

PDF, 1.34 MB

english, 1999

17

Hemifacial spasm in Parkinson's disease

Hideto Miwa, Asako Yoritaka, Yoshikuni Mizuno

Journal:

Movement Disorders

Year:

1999

Language:

english

File:

PDF, 836 KB

english, 1999

18

Dopaminergic neurons degenerate by apoptosis in Parkinson's disease

Etienne C. Hirsch, Stéphane Hunot, Baptiste Faucheux, Yves Agid, Yoshikuni Mizuno, Hideki Mochizuki, William G. Tatton, Nadine Tatton, Warren C. Olanow

Journal:

Movement Disorders

Year:

1999

Language:

english

File:

PDF, 32 KB

english, 1999

19

Association analysis of a polymorphism of the monoamine oxidase B gene with Parkinson's disease in a Japanese population

Yuji Morimoto, Nobuhiro Murayama, Akira Kuwano, Ikuko Kondo, Yoriaki Yamashita, Yoshikuni Mizuno

Journal:

American Journal of Medical Genetics Part A

Year:

1995

Language:

english

File:

PDF, 408 KB

english, 1995

20

A novel L266V mutation of the tau gene causes frontotemporal dementia with a unique tau pathology

Tomonori Kobayashi, Satoru Ota, Kuniaki Tanaka, Yuji Ito, Masato Hasegawa, Yuri Umeda, Yumiko Motoi, Masashi Takanashi, Masahiro Yasuhara, Midori Anno, Yoshikuni Mizuno, Hideo Mori

Journal:

Annals of Neurology

Year:

2003

Language:

english

File:

PDF, 1.68 MB

english, 2003

21

Possibility for neurogenesis in substantia nigra of parkinsonian brain

Kenji Yoshimi, Yong-Ri Ren, Tatsunori Seki, Masanori Yamada, Hideki Ooizumi, Masafumi Onodera, Yuko Saito, Shigeo Murayama, Hideyuki Okano, Yoshikuni Mizuno, Hideki Mochizuki

Journal:

Annals of Neurology

Year:

2005

Language:

english

File:

PDF, 1.19 MB

english, 2005

22

Adult type neuronal storage disease with neuraminidase deficiency

Dr. Tadashi Miyatake, Tetsushi Atsumi, Taminori Obayashi, Yoshikuni Mizuno, Susumu Ando, Toshio Ariga, Kyoko Matsui-Nakamura, Takamichi Yamada

Journal:

Annals of Neurology

Year:

1979

Language:

english

File:

PDF, 2.30 MB

english, 1979

23

Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in parkinson's disease

Nobutaka Hattori, Masashi Tanaka, Takayuki Ozawa, Dr. Yoshikuni Mizuno

Journal:

Annals of Neurology

Year:

1991

Language:

english

File:

PDF, 924 KB

english, 1991

24

An immunohistochemical study on α-ketoglutarate dehydrogenase complex in Parkinson's disease

Dr. Yoshikuni Mizuno, Sadayuki Matuda, Hiroyo Yoshino, Hideo Mori, Nobutaka Hattori, Shin-Ichirou Ikebe

Journal:

Annals of Neurology

Year:

1994

Language:

english

File:

PDF, 730 KB

english, 1994

25

A clue to the pathogenesis of dopa-responsive dystonia

Yoshiaki Furukawa, Yoshikuni Mizuno, Katsunori Nishi, Hirotaro Narabayashi

Journal:

Annals of Neurology

Year:

1995

Language:

english

File:

PDF, 149 KB

english, 1995

26

GTP-cyclohydrolase I gene mutations in hereditary progressive and dopa-responsive dystonia

Dr Yoshiaki Furukawa, Mitsunobu Shimadzu, Ali H. Rajput, Yumiko Shimuzu, Tetsuzo Tagawa, Hideo Mori, Masayuki Yokochi, Hirotaro Narabayashi, Oleh Hornykiewicz, Yoshikuni Mizuno, Stephen J. Kish

Journal:

Annals of Neurology

Year:

1996

Language:

english

File:

PDF, 973 KB

english, 1996

27

Association between the gene encoding the E2 subunit of the α-ketoglutarate dehydrogenase complex and Parkinson's disease

Dr Tomonori Kobayashi, Hiroto Matsumine, Sadayuki Matuda, Yoshikuni Mizuno

Journal:

Annals of Neurology

Year:

1998

Language:

english

File:

PDF, 379 KB

english, 1998

28

Posterior hypoperfusion in parkinson's disease With and without dementia measured with arterial spin labeling MRI

Koji Kamagata, Yumiko Motoi, Masaaki Hori, Michimasa Suzuki, Atsushi Nakanishi, Keigo Shimoji, Shinsuke Kyougoku, Ryohei Kuwatsuru, Keisuke Sasai, Osamu Abe, Yoshikuni Mizuno, Shigeki Aoki, Nobutaka H

Journal:

Journal of Magnetic Resonance Imaging

Year:

2011

Language:

english

File:

PDF, 154 KB

english, 2011

29

Decline of striatal dopamine release in parkin-deficient mice shown by ex vivo autoradiography

Shigeto Sato, Tomoki Chiba, Shingo Nishiyama, Takeharu Kakiuchi, Hideo Tsukada, Taku Hatano, Takahiro Fukuda, Yasunobu Yasoshima, Nobuyuki Kai, Kazuto Kobayashi, Yoshikuni Mizuno, Keiji Tanaka, Nobuta

Journal:

Journal of Neuroscience Research

Year:

2006

Language:

english

File:

PDF, 738 KB

english, 2006

30

Randomized, double-blind study of pramipexole with placebo and bromocriptine in advanced Parkinson's disease

Yoshikuni Mizuno, Nobuo Yanagisawa, Sadako Kuno, Mitsutoshi Yamamoto, Kazuko Hasegawa, Hideki Origasa, Hisayuki Kowa

Journal:

Movement Disorders

Year:

2003

Language:

english

File:

PDF, 103 KB

english, 2003

31

Myoclonic tremor in patients with parkinsonian-type multiple system atrophy

Yasuyuki Okuma, Yoshikuni Mizuno

Journal:

Movement Disorders

Year:

2001

Language:

english

File:

PDF, 17 KB

english, 2001

32

Myoclonic tremulous movements in multiple system atrophy are a form of cortical myoclonus

Yasuyuki Okuma, Kenji Fujishima, Hideto Miwa, Hideo Mori, Yoshikuni Mizuno

Journal:

Movement Disorders

Year:

2005

Language:

english

File:

PDF, 124 KB

english, 2005

33

Preserved cardiac sympathetic nerve accounts for normal cardiac uptake of MIBG in PARK2

Satoshi Orimo, Takeshi Amino, Masayuki Yokochi, Tohru Kojo, Toshiki Uchihara, Atsushi Takahashi, Koichi Wakabayashi, Hitoshi Takahashi, Nobutaka Hattori, Yoshikuni Mizuno

Journal:

Movement Disorders

Year:

2005

Language:

english

File:

PDF, 113 KB

english, 2005

34

Recessive Parkinson's disease

Shin-Ichiro Kubo, Nobutaka Hattori, Yoshikuni Mizuno

Journal:

Movement Disorders

Year:

2006

Language:

english

File:

PDF, 92 KB

english, 2006

35

Prognosis of Parkinson's disease: Time to stage III, IV, V, and to motor fluctuations

Kenichi Sato, Taku Hatano, Kazuo Yamashiro, Maki Kagohashi, Kenya Nishioka, Nana Izawa, Hideki Mochizuki, Nobutaka Hattori, Hideo Mori, Yoshikuni Mizuno

Journal:

Movement Disorders

Year:

2006

Language:

english

File:

PDF, 259 KB

english, 2006

36

Placebo-controlled, double-blind dose-finding study of entacapone in fluctuating parkinsonian patients

Yoshikuni Mizuno, Ichiro Kanazawa, Sadako Kuno, Nobuo Yanagisawa, Mitsutoshi Yamamoto, Tomoyoshi Kondo

Journal:

Movement Disorders

Year:

2007

Language:

english

File:

PDF, 63 KB

english, 2007

37

Ropinirole is effective on motor function when used as an adjunct to levodopa in Parkinson's disease: STRONG study

Yoshikuni Mizuno, Takashi Abe, Kazuko Hasegawa, Sadako Kuno, Tomoyoshi Kondo, Mitsutoshi Yamamoto, Mitsuyoshi Nakashima, Ichiro Kanazawa

Journal:

Movement Disorders

Year:

2007

Language:

english

File:

PDF, 163 KB

english, 2007

38

Preface

Yoshikuni Mizuno, Gregor K. Wenning

Journal:

Movement Disorders

Year:

2007

Language:

english

File:

PDF, 38 KB

english, 2007

39

The frequency of cardiac valvular regurgitation in Parkinson's disease

Kazuo Yamashiro, Miki Komine-Kobayashi, Taku Hatano, Takao Urabe, Hideki Mochizuki, Nobutaka Hattori, Yoshitaka Iwama, Hiroyuki Daida, Michi Sakai, Takeo Nakayama, Yoshikuni Mizuno

Journal:

Movement Disorders

Year:

2008

Language:

english

File:

PDF, 171 KB

english, 2008

40

Mutation analyses in amyotrophic lateral sclerosis/parkinsonism–dementia complex of the Kii peninsula, Japan

Hiroyuki Tomiyama, Yasumasa Kokubo, Ryogen Sasaki, Yuanzhe Li, Yoko Imamichi, Manabu Funayama, Yoshikuni Mizuno, Nobutaka Hattori, Shigeki Kuzuhara

Journal:

Movement Disorders

Year:

2008

Language:

english

File:

PDF, 99 KB

english, 2008

41

Rapid screening of ATP13A2 variant with high-resolution melting analysis

Manabu Funayama, Hiroyuki Tomiyama, Ruey-Meei Wu, Kotaro Ogaki, Hiroyo Yoshino, Yoshikuni Mizuno, Nobutaka Hattori

Journal:

Movement Disorders

Year:

2010

Language:

english

File:

PDF, 887 KB

english, 2010

42

Clinical efficacy of istradefylline (KW-6002) in Parkinson's disease: A randomized, controlled study

Yoshikuni Mizuno, Kazuko Hasegawa, Tomoyoshi Kondo, Sadako Kuno, Mitsutoshi Yamamoto

Journal:

Movement Disorders

Year:

2010

Language:

english

File:

PDF, 164 KB

english, 2010

43

Rationale for delayed-start study of pramipexole in Parkinson's disease: The PROUD study

Anthony H.V. Schapira, Stefan Albrecht, Paolo Barone, Cynthia L. Comella, Michael P. McDermott, Yoshikuni Mizuno, Werner Poewe, Olivier Rascol, Kenneth Marek

Journal:

Movement Disorders

Year:

2010

Language:

english

File:

PDF, 112 KB

english, 2010

44

Efficacy, safety, and tolerability of overnight switching from immediate- to once daily extended-release pramipexole in early Parkinson's disease

Olivier Rascol, Paolo Barone, Robert A. Hauser, Yoshikuni Mizuno, Werner Poewe, Anthony H.V. Schapira, Laurence Salin, Mandy Sohr, Catherine Debieuvre, for the Pramipexole Switch Study Group

Journal:

Movement Disorders

Year:

2010

Language:

english

File:

PDF, 132 KB

english, 2010

45

Randomized, double-blind, multicenter evaluation of pramipexole extended release once daily in early Parkinson's disease

Robert A. Hauser, Anthony H.V. Schapira, Olivier Rascol, Paolo Barone, Yoshikuni Mizuno, Laurence Salin, Monika Haaksma, Nolwenn Juhel, Werner Poewe

Journal:

Movement Disorders

Year:

2010

Language:

english

File:

PDF, 220 KB

english, 2010

46

Milestones in PD genetics

Thomas Gasser, John Hardy, Yoshikuni Mizuno

Journal:

Movement Disorders

Year:

2011

Language:

english

File:

PDF, 247 KB

english, 2011

47

Mitochondrial abnormalities in Parkinson's disease

Yoshikuni Mizuno, Shin-Ichirou Ikebe, Nobutaka Hattori, Yuko Nakagawa-Hattori, Masashi Tanaka, Takayuki Ozawa

Journal:

Movement Disorders

Year:

1992

Language:

english

File:

PDF, 130 KB

english, 1992

48

Clinical trial of piracetam in patients with myoclonus: Nationwide multiinstitution study in Japan

Dr. Akio Ikeda, Hiroshi Shibasaki, Kunio Tasgiro, Yoshikuni Mizuno, Jun Kimura

Journal:

Movement Disorders

Year:

1996

Language:

english

File:

PDF, 1024 KB

english, 1996

49

Autosomal recessive juvenile parkinsonism: A key to understanding nigral degeneration in sporadic Parkinson's disease

Nobutaka Hattori, Hideki Shimura, Shin-ichiro Kubo, Tohru Kitada, Mei Wang, Shuichi Asakawa, Shinsei Minashima, Nobuyoshi Shimizu, Toshiaki Suzuki, Keiji Tanaka, Yoshikuni Mizuno

Journal:

Year:

2000

Language:

english

File:

PDF, 410 KB

english, 2000

50

Genotype–phenotype correlation: Familial Parkinson disease

Hideo Mori, Nobutaka Hattori, Yoshikuni Mizuno

Journal:

Year:

2003

Language:

english

File:

PDF, 223 KB

english, 2003